Suzanne Chazin was born in Manhattan and raised in Tenafly, NJ, the only child of immigrants. Her father was born in Russia. Her mother was born and raised in England.
A former journalist, Suzanne is the award-winning author of two mystery series. Her first stars Georgia Sheehan, an FDNY firefighter-turned-fire investigator (The Fourth Angel, Flashover and Fireplay). Her second stars Jimmy Vega, an upstate NY homicide detective navigating the world of the undocumented (Land of Careful Shadows, A Blossom of Bright Light, No Witness But the Moon).
The Georgia Skeehan/FDNY series was inspired by Suzanne's husband who is a high-ranking chief in the FDNY. The Jimmy Vega series was inspired by Suzanne's work with Latino immigrants near her home in Westchester County, NY. A Blossom of Bright Light, book #2 in the series, was an Amazon "mystery pick of the month." Land of Careful Shadows, book #1, was chosen among the top five mystery books of 2016 by the American Library Association.
Chemotaxis inhibitory protein of staphylococci (CHIPS) and Staphylococcal complement inhibitor (SCIN) are small, excreted molecules that play a crucial role in the staphylococcal defence against the human innate immune system. Here we show that they both counteract crucial acute responses of our immune system such as complement activation, neutrophil chemotaxis and neutrophil activation. By studying gene expression via promoter–green fluorescent protein fusions, Northern blots and protein expression analyses, we show that SCIN and CHIPS are produced during the early (exponential) growth stages. Although the SCIN and CHIPS genes are expressed simultaneously, they are differently regulated by various Staphylococcus aureus regulatory loci. However, the sae locus is crucial for upregulation of both SCIN and CHIPS. This is the first study that presents the expression of two extracellular S. aureus proteins early during growth. Because SCIN and CHIPS are both efficient modulators of neutrophil chemotaxis, phagocytosis and killing, their early expression is necessary for efficient modulation of the early immune response.